Development of spray-dried chitosan microcarriers for nanoparticle delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F13%3A43895516" target="_blank" >RIV/60461373:22330/13:43895516 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/13:43895516
Result on the web
<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.005" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2012.12.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.005" target="_blank" >10.1016/j.powtec.2012.12.005</a>
Alternative languages
Result language
angličtina
Original language name
Development of spray-dried chitosan microcarriers for nanoparticle delivery
Original language description
The design of chitosan microspheres for the encapsulation and release of nanoparticles has been considered. The composite microcarriers have been produced by spray drying and the effect of factors including the chitosan cross-linking ratio (using tri-polyphosphate as the cross-linking agent), nanoparticle loading in the polymer matrix and the internal structure of the microspheres (uniform dispersion of nanoparticles vs. core-shell structure) on the in vitro release kinetics have been systematically investigated. The antibacterial performance of the composite microspheres containing Ag nanoparticles has been evaluated against three different strains of bacteria in a suspension culture. The bioadhesive character of the chitosan carrier particles has lead to the formation of stable aggregates with the bacteria, which enhanced the antibacterial efficacy of the released nanoparticles through the contact mechanism.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/MEB061108" target="_blank" >MEB061108: Development of chitosan based biomedical polymers with antibacterial properties</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Powder Technology
ISSN
0032-5910
e-ISSN
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Volume of the periodical
235
Issue of the periodical within the volume
February 2013
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
797-805
UT code for WoS article
000316039400098
EID of the result in the Scopus database
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