ENCAPSULATION OF LACCASE IN CHITOSAN MICRO-CARRIERS BY TWO-FLUID AND THREE-FLUID NOZZLE

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893673" target="_blank" >RIV/60461373:22340/12:43893673 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
ENCAPSULATION OF LACCASE IN CHITOSAN MICRO-CARRIERS BY TWO-FLUID AND THREE-FLUID NOZZLE
Original language description
Chitosan is a biocompatible and biodegradable polymer suitable for the encapsulation of both small molecules and biomolecules. The simultaneous encapsulation of a precursor (substrate) and immobilization of catalyst (enzyme) in a core-shell chitosan particle makes it possible to deliver active molecules with a short half-life by forming them in-situ from stable precursors. This is desirable e.g. in the case of biocidal molecules or sensorially active substances. The first objective of our study is to investigate the effect of composition (in particular, the TPP/chitosan ratio) and cross-linking method (ex-situ vs. in-situ) on the properties of chitosan microspheres formed by spray drying. The particle size distribution, particle morphology, zeta potential and swelling behaviour have been systematically investigated. A novel cross-linking method, based on in-situ contact of TPP and chitosan solutions directly at the nozzle orifice (3-fluid nozzle), has been developed and compared with a
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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