Stabilization of the beta-hairpin in Mason-Pfizer Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43897364" target="_blank" >RIV/60461373:22330/14:43897364 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s12977-014-0094-8" target="_blank" >http://dx.doi.org/10.1186/s12977-014-0094-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12977-014-0094-8" target="_blank" >10.1186/s12977-014-0094-8</a>

Result language

angličtina

Original language name

Stabilization of the beta-hairpin in Mason-Pfizer Stabilization of the beta-hairpin in Mason-Pfizer monkey virus capsid protein- a critical step for infectivity

Original language description

Formation of a mature core is a crucial event for infectivity of retroviruses such as Mason-Pfizer monkey virus (M-PMV). The process is triggered by proteolytic cleavage of the polyprotein precursor Gag, which releases matrix, capsid (CA), and nucleocapsid proteins. Once released, CA assembles to form a mature core - a hexameric lattice protein shell that protects retroviral genomic RNA. Subtle conformational changes within CA induce the transition from the immature lattice to the mature lattice. Upon release from the precursor, the initially unstructured N-terminus of CA is refolded to form a beta-hairpin stabilized by a salt bridge between the N-terminal proline and conserved aspartate. Although the crucial role of the beta-hairpin in the mature coreassembly has been confirmed, its precise structural function remains poorly understood.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Retrovirology

ISSN

1742-4690

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

94

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1-15

UT code for WoS article

000344571100001

EID of the result in the Scopus database

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