The complex understanding of Annexin A1 phosphorylation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43897524" target="_blank" >RIV/60461373:22330/14:43897524 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S089865681300301X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S089865681300301X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellsig.2013.09.020" target="_blank" >10.1016/j.cellsig.2013.09.020</a>

Result language
angličtina
Original language name
The complex understanding of Annexin A1 phosphorylation
Original language description
Annexin A1 (ANXA1) is the first characterized member of the annexins superfamily. It binds the cellular membrane phospholipids in Ca2+ regulated manner. Annexin A1 has been found in several tissues and many physiological roles as hormones secretion, vesiculation, inflammatory response, apoptosis and differentiation have been shown. Its subcellular localization and binding with many partner proteins are altered accordingly with its physiological role. The Annexin A1 membrane localization is crucial for binding to receptors, suggesting a paracrine and juxtacrine extracellular action. Annexin A1 is subjected to several post-translational modifications. In particular the protein is phosphorylated on several residues both on the N-terminal functional domainand on the C-terminus core. Different kinases have been identified as responsible for the phosphotylation status of selective residues. The specific change in the phosphorylation status on the different sites alters ANXA1 localization, b
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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