The relationship between structure and in vitro antibacterial activity of selected isoflavones and their metabolites with special focus on antistaphylococcal effect of demethyltexasin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43898485" target="_blank" >RIV/60461373:22330/15:43898485 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41340/15:68603

Result on the web

<a href="http://dx.doi.org/10.1111/lam.12361" target="_blank" >http://dx.doi.org/10.1111/lam.12361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/lam.12361" target="_blank" >10.1111/lam.12361</a>

Result language

angličtina

Original language name

The relationship between structure and in vitro antibacterial activity of selected isoflavones and their metabolites with special focus on antistaphylococcal effect of demethyltexasin

Original language description

In this study, we tested 15 naturally occurring isoflavones and their metabolites for their possible antibacterial properties against nine Gram-positive and Gram-negative bacteria. The in vitro antibacterial activity was determined using the broth microdilution method, and the results were expressed as minimum inhibitory concentrations (MICs). 6,7,4'-trihydroxyisoflavone (demethyltexasin), 7,3',4'-trihydroxyisoflavone (hydroxydaidzein), 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A), 7,8,4'-trihydroxyisoflavone (demethylretusin) and 5,7,4'-trihydroxyisoflavone (genistein) produced significant antibacterial activity (MICsGREATER-THAN OR EQUAL TO16mugml(-1) ). The most effective compound, demethyltexasin, was subsequently tested for its growth-inhibitory effect against Staphylococcus aureus, and it exhibited significant antistaphylococcal effects against various standard strains and clinical isolates, including methicillin and tetracycline resistant ones with the MICs ranging from 16 to 128mugml(-1) .

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GM - Food industry

OECD FORD branch

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Project

<a href="/en/project/GA525%2F09%2F0994" target="_blank" >GA525/09/0994: Chemotaxonomy of isoflavonoids</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

LETTERS IN APPLIED MICROBIOLOGY

ISSN

0266-8254

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

242-247

UT code for WoS article

000349623000007

EID of the result in the Scopus database

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