Stabilization of hyaluronan-based materials by peptide conjugation and its use as a cell-seeded scaffold in tissue engineering

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F18%3A43915840" target="_blank" >RIV/60461373:22330/18:43915840 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/18:00495240

Result on the web

<a href="http://dx.doi.org/10.1016/j.carbpol.2018.08.082" target="_blank" >http://dx.doi.org/10.1016/j.carbpol.2018.08.082</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carbpol.2018.08.082" target="_blank" >10.1016/j.carbpol.2018.08.082</a>

Result language

angličtina

Original language name

Stabilization of hyaluronan-based materials by peptide conjugation and its use as a cell-seeded scaffold in tissue engineering

Original language description

New materials based on molecules naturally occurred in body are assumed to be fully biocompatible and biodegradable. In our study, we used hyaluronic acid (HA) modified with peptides, which meet all this criterion and could be advantageously used in tissue engineering. Peptides with RGD, IKVAV or SIKVAV adhesive motif were attached to HA-based fiber or non-woven textile through ester bond in the term of solid phase peptide synthesis. A linker between HA and peptide containing three glycine or two 6-aminohexanoyl units was applied to make peptides more available for cell surface receptors. Dermal fibroblasts adhered readily on this material, preferentially to RGD peptide with 6-aminohexanoyl linker. Contrary, the absence of adhesive peptide did not allow the cell attachment but maintained the material stability. © 2018 Elsevier Ltd

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10401 - Organic chemistry

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carbohydrate Polymers

ISSN

0144-8617

e-ISSN

—

Volume of the periodical

201

Issue of the periodical within the volume

01.12.2018

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

300-307

UT code for WoS article

000445030100032

EID of the result in the Scopus database

2-s2.0-85052142284