Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F19%3A43917984" target="_blank" >RIV/60461373:22330/19:43917984 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/18:76778 RIV/60460709:41340/18:76778 RIV/60460709:41340/19:79954 RIV/60460709:41210/19:79954
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1462180" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1462180</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14786419.2018.1462180" target="_blank" >10.1080/14786419.2018.1462180</a>

Result language
angličtina
Original language name
Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
Original language description
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 mu g TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40401 - Agricultural biotechnology and food biotechnology

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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