Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43920823" target="_blank" >RIV/60461373:22330/20:43920823 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10425690 RIV/00064165:_____/21:10425690

Result on the web

<a href="https://link.springer.com/article/10.1007/s12602-020-09675-2#citeas" target="_blank" >https://link.springer.com/article/10.1007/s12602-020-09675-2#citeas</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12602-020-09675-2" target="_blank" >10.1007/s12602-020-09675-2</a>

Result language

angličtina

Original language name

Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections

Original language description

Lactobacilli in the vaginal tract are essential to protect against microbial infections. We therefore focused on isolating vaginal lactobacilli from pregnant women and testing their functional properties. Lactobacilli were isolated from 50 vaginal swabs and the purified isolates were identified by MALDI-TOF MS. Functional properties (antimicrobial activity, organic acids and hydrogen peroxide production, antibiotic susceptibility, auto-aggregation, and hydrophobicity) of selected isolates were tested. Lactobacilli (41 strains) were identified in 58% of swabs with a predominance ofLactobacillus crispatus(48%) followed byL. jensenii(21%),L. rhamnosus(14%),L. fermentum(10%), andL. gasseri(7%). The highest antibacterial activity was determined forL. fermentumandL. rhamnosus. Strong anti-Candidaactivity was observed for strainsL. crispatus,L. fermentum, andL. rhamnosus. StrainL. jensenii58C possessed the highest production of hydrogen peroxide (6.32 +/- 0.60 mg/l). The best lactic acid producer was strainL. rhamnosus72A (11.6 +/- 0.2 g/l). All strains were resistant to fluconazole and metronidazole. The highest auto-aggregation was observed for strainL. crispatus51A (98.8 +/- 0.1% after 24 h). StrainL. rhamnosus68A showed the highest hydrophobicity (69.1 +/- 1.4%). StrainsL. fermentumandL. rhamnosusshowed high antibacterial activity and hydrophobicity, and strainsL. crispatuspossessed high auto-aggregation and anti-Candidaactivity. Thus, these strains alone or in a mix could be used for the preparation of probiotic products for treatment and prevention of vulvovaginal infections of pregnant and non-pregnant women.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PROBIOTICS AND ANTIMICROBIAL PROTEINS

ISSN

1867-1306

e-ISSN

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Volume of the periodical

Neuveden

Issue of the periodical within the volume

2020 Jun 24

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

000543006100001

EID of the result in the Scopus database

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