Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F20%3A43921342" target="_blank" >RIV/60461373:22330/20:43921342 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/20:00525575
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c01173" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c01173</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.inorgchem.0c01173" target="_blank" >10.1021/acs.inorgchem.0c01173</a>
Alternative languages
Result language
angličtina
Original language name
Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications
Original language description
Two new octahedral molybdenum cluster complexes act as an efficient singlet oxygen supplier in the context of the photodynamic therapy of cancer cells under blue-light irradiation. These complexes integrate the {Mo6I8}4+ core with 4′-carboxybenzo-15-crown-5 or cholate apical ligands and were characterized by 1H NMR, HR ESI-MS, and CHN elemental analysis. Both complexes display high quantum yields of luminescence and singlet oxygen formation in aqueous media associated with a suitable stability against hydrolysis. They are internalized into lysosomes of HeLa cells with no dark toxicity at pharmacologically relevant concentrations and have a strong phototoxic effect under blue-light irradiation, even in the presence of fetal bovine serum. The last feature is essential for further translation to in vivo experiments. Overall, these complexes are attractive molecular photosensitizers toward photodynamic applications. Copyright © 2020 American Chemical Society.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic Chemistry
ISSN
0020-1669
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
9287-9293
UT code for WoS article
000548456300068
EID of the result in the Scopus database
2-s2.0-85087531460