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Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F22%3A00559289" target="_blank" >RIV/61388980:_____/22:00559289 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378050:_____/22:00559289 RIV/60461373:22330/22:43924567

  • Result on the web

    <a href="https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00141a" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00141a</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1039/d2tb00141a" target="_blank" >10.1039/d2tb00141a</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles

  • Original language description

    X-Ray-induced photodynamic therapy represents a suitable modality for the treatment of various malignancies. It is based on the production of reactive oxygen species by radiosensitizing nanoparticles activated by X-rays. Hence, it allows overcoming the depth-penetration limitations of conventional photodynamic therapy and, at the same time, reducing the dose needed to eradicate cancer in the frame of radiotherapy treatment. The direct production of singlet oxygen by octahedral molybdenum cluster complexes upon X-ray irradiation is a promising avenue in order to simplify the architecture of radiosensitizing systems. One such complex was utilized to prepare water-stable nanoparticles using the solvent displacement method. The nanoparticles displayed intense red luminescence in aqueous media, efficiently quenched by oxygen to produce singlet oxygen, resulting in a substantial photodynamic effect under blue light irradiation. A robust radiosensitizing effect of the nanoparticles was demonstrated in vitro against TRAMP-C2 murine prostatic carcinoma cells at typical therapeutic X-ray doses. Injection of a suspension of the nanoparticles to a mouse model revealed the absence of acute toxicity as evidenced by the invariance of key physiological parameters. This study paves the way for the application of octahedral molybdenum cluster-based radiosensitizers in X-ray-induced photodynamic therapy and its translation to in vivo experiments.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10402 - Inorganic and nuclear chemistry

Result continuities

  • Project

    <a href="/en/project/GA21-11688S" target="_blank" >GA21-11688S: Core-shell nanoparticles for targeted X-ray-induced photodynamic therapy</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Materials Chemistry B

  • ISSN

    2050-750X

  • e-ISSN

    2050-7518

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    3303-3310

  • UT code for WoS article

    000778336400001

  • EID of the result in the Scopus database

    2-s2.0-85129173177