Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F22%3A00559289" target="_blank" >RIV/61388980:_____/22:00559289 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/22:00559289 RIV/60461373:22330/22:43924567
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00141a" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00141a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2tb00141a" target="_blank" >10.1039/d2tb00141a</a>
Alternative languages
Result language
angličtina
Original language name
Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles
Original language description
X-Ray-induced photodynamic therapy represents a suitable modality for the treatment of various malignancies. It is based on the production of reactive oxygen species by radiosensitizing nanoparticles activated by X-rays. Hence, it allows overcoming the depth-penetration limitations of conventional photodynamic therapy and, at the same time, reducing the dose needed to eradicate cancer in the frame of radiotherapy treatment. The direct production of singlet oxygen by octahedral molybdenum cluster complexes upon X-ray irradiation is a promising avenue in order to simplify the architecture of radiosensitizing systems. One such complex was utilized to prepare water-stable nanoparticles using the solvent displacement method. The nanoparticles displayed intense red luminescence in aqueous media, efficiently quenched by oxygen to produce singlet oxygen, resulting in a substantial photodynamic effect under blue light irradiation. A robust radiosensitizing effect of the nanoparticles was demonstrated in vitro against TRAMP-C2 murine prostatic carcinoma cells at typical therapeutic X-ray doses. Injection of a suspension of the nanoparticles to a mouse model revealed the absence of acute toxicity as evidenced by the invariance of key physiological parameters. This study paves the way for the application of octahedral molybdenum cluster-based radiosensitizers in X-ray-induced photodynamic therapy and its translation to in vivo experiments.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/GA21-11688S" target="_blank" >GA21-11688S: Core-shell nanoparticles for targeted X-ray-induced photodynamic therapy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Materials Chemistry B
ISSN
2050-750X
e-ISSN
2050-7518
Volume of the periodical
10
Issue of the periodical within the volume
17
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
3303-3310
UT code for WoS article
000778336400001
EID of the result in the Scopus database
2-s2.0-85129173177