PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00585208" target="_blank" >RIV/68378050:_____/24:00585208 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/24:00585208 RIV/60461373:22330/24:43929313 RIV/60461373:22340/24:43929313
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c00084" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c00084</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.inorgchem.4c00084" target="_blank" >10.1021/acs.inorgchem.4c00084</a>
Alternative languages
Result language
angličtina
Original language name
PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma
Original language description
The combination of photodynamic therapy and radiotherapy has given rise to a modality called radiodynamic therapy (RDT), based on reactive oxygen species-producing radiosensitizers. The production of singlet oxygen, O-2((1)Delta(g)), by octahedral molybdenum (Mo-6) clusters upon X-ray irradiation allows for simplification of the architecture of radiosensitizing systems. In this context, we prepared a radiosensitizing system using copper-free click chemistry between a Mo-6 cluster bearing azido ligands and the homo-bifunctional linker bis-dPEG(11)-DBCO. The resulting compound formed nanoparticles, which featured production of O-2((1)Delta(g)) and efficient cellular uptake, leading to remarkable photo- and radiotoxic effects against the prostatic adenocarcinoma TRAMP-C2 cell line. Spheroids of TRAMP-C2 cells were also used for evaluation of toxicity and phototoxicity. In vivo experiments on a mouse model demonstrated that subcutaneous injection of the nanoparticles is a safe administration mode at a dose of up to 0.08 g kg(-1). The reported results confirm the relevancy of Mo-6-based radiosensitizing nanosystems for RDT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA21-11688S" target="_blank" >GA21-11688S: Core-shell nanoparticles for targeted X-ray-induced photodynamic therapy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic Chemistry
ISSN
0020-1669
e-ISSN
1520-510X
Volume of the periodical
63
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
4419-4428
UT code for WoS article
001166802200001
EID of the result in the Scopus database
2-s2.0-85186243334