Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00491206" target="_blank" >RIV/61388980:_____/18:00491206 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/18:00491206 RIV/68407700:21340/18:00328132 RIV/60461373:22330/18:43916976

Result on the web

<a href="http://dx.doi.org/10.1039/c8tb00893k" target="_blank" >http://dx.doi.org/10.1039/c8tb00893k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c8tb00893k" target="_blank" >10.1039/c8tb00893k</a>

Result language

angličtina

Original language name

Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

Original language description

The use of radiosensitizers recently emerged as a promising approach to circumvent the depth penetration limitations of photodynamic therapy of cancer and to enhance radiotherapeutical effects. A widely explored current strategy is based on complex nanoarchitectures that facilitate the transfer of energy harvested from X-ray radiation by scintillating nanoparticles to the surrounding photosensitizer molecules to generate reactive oxygen species, mostly singlet oxygen O-2((1)Delta(g)). We describe an alternative approach aiming at a considerable simplification of the architecture. The presented nanoparticles, made of the luminescent octahedral molybdenum cluster compound (n-Bu4N)(2)[Mo6I8(OCOCF3)(6)], efficiently absorb X-rays due to the high content of heavy elements, leading to the formation of the excited triplet states that interact with molecular oxygen to produce O-2((1)Delta(g)). The activity of the nanoparticles on HeLa cells was first investigated under UVA/blue-light irradiation in order to prove the biological effects of photosensitized O-2((1)Delta(g)), there is no dark toxicity at micromolar concentrations, but strong phototoxicity in the nanomolar range. The nanoparticles significantly enhance the antiproliferative effect of X-ray radiation in vitro at lower concentration than for previously reported O-2((1)Delta(g)) radiosensitizing systems and this effect is more pronounced on cancer HeLa cells than non-cancer MRC cells. The results demonstrate that the clusterbased radiosensitizers of O-2((1)Delta(g)) have strong potential with respect to the enhancement of the efficacy of radiotherapy with exciting opportunities for cancer treatment.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

26

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

4301-4307

UT code for WoS article

000437470100003

EID of the result in the Scopus database

2-s2.0-85049638622