The effect of iodide and temperature on enhancing antibacterial properties of nanoparticles with an encapsulated photosensitizer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F19%3A00510021" target="_blank" >RIV/61388955:_____/19:00510021 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/19:00510021 RIV/00216208:11310/19:10394050
Result on the web
<a href="http://hdl.handle.net/11104/0300594" target="_blank" >http://hdl.handle.net/11104/0300594</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfb.2019.01.021" target="_blank" >10.1016/j.colsurfb.2019.01.021</a>
Alternative languages
Result language
angličtina
Original language name
The effect of iodide and temperature on enhancing antibacterial properties of nanoparticles with an encapsulated photosensitizer
Original language description
Aqueous dispersions of sulfonated polystyrene nanoparticles (average diameter: 30 +/- 14 nm) with encapsulated 5,10,15,20-tetraphenylporphyrin (TPP) are promising candidates for antibacterial treatments due to the photogeneration of cytotoxic singlet oxygen species O-2((1)Delta(g)) under physiological conditions using visible light. The antibacterial effect on gram-negative Escherichia coli was significantly enhanced after the addition of nontoxic potassium iodide (0.001-0.01 M) because photogenerated O-2((1)Delta(g)) oxidized iodide to I-2/I-3(-), which is another antibacterial species. The improved antibacterial properties were predicted using luminescence measurements of O-2((1)Delta(g)), transient absorption of TPP triplets and singlet oxygen-sensitized delayed fluorescence (SODF). In contrast to a solution of free photosensitizers, the aqueous dispersion of photoactive nanoparticles did not exhibit any quenching of the excited states after the addition of iodide or any tendency toward aggregation and/or I-3(-)-induced photo-aggregation. We also observed a decrease in the lifetime of O-2((1)Delta(g)) and a significant increase in SODF intensity at higher temperatures, due to the increased oxygen diffusion coefficient in nanoparticles and aqueous surroundings. This effect corresponds with the significantly stronger antibacterial effect of nano particles at physiological temperature (37 degrees C) in comparison with that at room temperature (25 degrees C).
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GA16-15020S" target="_blank" >GA16-15020S: Photoactive Polymer Materials with Nanostructured Surfaces for Biomedical Applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces B-Biointerfaces
ISSN
0927-7765
e-ISSN
—
Volume of the periodical
176
Issue of the periodical within the volume
APR 2019
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
334-340
UT code for WoS article
000465051800038
EID of the result in the Scopus database
2-s2.0-85059834822