Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10380272" target="_blank" >RIV/00216208:11310/18:10380272 - isvavai.cz</a>
Alternative codes found
RIV/61388980:_____/18:00487024 RIV/61388955:_____/18:00487024 RIV/61989592:15110/18:73590485
Result on the web
<a href="https://doi.org/10.1039/c7nr08822a" target="_blank" >https://doi.org/10.1039/c7nr08822a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7nr08822a" target="_blank" >10.1039/c7nr08822a</a>
Alternative languages
Result language
angličtina
Original language name
Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers
Original language description
Novel therapies to prevent bacterial infections are of utmost importance in biomedical research due to the emergence of multidrug-resistant strains of bacteria. Herein, we report the preparation, characterization and antibacterial evaluation of sulfonated polystyrene nanoparticles simultaneously releasing two antibacterial species, nitric oxide (NO) and singlet oxygen (O-2((1)Delta(g))), upon irradiation with visible light. The nanoparticles were prepared by simple and scalable processes from nanofiber membranes with an encapsulated NO photodonor and/or ionically entangled tetracationic porphyrin/phthalocyanine photosensitizers. The release of NO and O-2((1)Delta(g)) from the polystyrene nanoparticles is controlled by light wavelength and dose, as well as by temperature, which influences the diffusion coefficient and solubility of both species in the polystyrene matrix. The concentrations of NO and O-2((1)Delta(g)) were measured by amperometric and time-resolved spectroscopic techniques and by chemical analysis. Due to the efficient photogeneration of both species at physiological temperature and resultant strong antibacterial action observed on Escherichia coli, the nanoparticles are a promising material for antibacterial applications triggered/modulated by light and temperature.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale
ISSN
2040-3364
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
2639-2648
UT code for WoS article
000424075400053
EID of the result in the Scopus database
2-s2.0-85041454084