Antibiofilm agent pterostilbene is able to enhance antibiotics action against Staphylococcus epidermidis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43921091" target="_blank" >RIV/60461373:22330/21:43921091 - isvavai.cz</a>

Result on the web

<a href="https://www.researchgate.net/publication/346411401_Antibiofilm_agent_pterostilbene_is_able_to_enhance_antibiotics_action_against_Staphylococcus_epidermidis" target="_blank" >https://www.researchgate.net/publication/346411401_Antibiofilm_agent_pterostilbene_is_able_to_enhance_antibiotics_action_against_Staphylococcus_epidermidis</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.micpath.2020.104632" target="_blank" >10.1016/j.micpath.2020.104632</a>

Result language

angličtina

Original language name

Antibiofilm agent pterostilbene is able to enhance antibiotics action against Staphylococcus epidermidis

Original language description

Pterostilbene (PTE) is a naturally occurring compound originally isolated from Pterocarpus spp. It has been widely used in traditional Indian medicine and later discovered to have various beneficial pharmacological effects such as antioxidant properties, hypoglycaemic or antitumor, and antimicrobial activity. This work is focused on demonstrating PTE synergistic effect with erythromycin and tetracycline to reduce their needed effective concentration for suppression of Staphylococcus epidermidis planktonic cells growth and biofilm formation. The secondary aim is to find these combinations effect on the production of its virulence factors. PTE was found to be effective in inhibition of its planktonic cells with MIC80 values 25–37.5 mg l−1. Simultaneously, it decreased the metabolic activity of biofilm cells and was especially effective on a clinical isolate (MBIC80 = 35 mg l−1) in contrast to the conventional antibiotics. In combination, PTE helped the antibiotics to overcome the tolerance of S. epidermidis biofilm cells (5 mg l−1 of each antibiotic with 49 mg l−1 PTE caused more than 85% inhibition of metabolic activity). It permeabilized cytoplasmic membrane of S. epidermidis cells and altered their surface hydrophobicity. Therefore, PTE has a great potential to enhance antibiotics action in the treatment of infections caused by this pathogen.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microbial Pathogenesis

ISSN

0882-4010

e-ISSN

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Volume of the periodical

neuveden

Issue of the periodical within the volume

November 2020

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1-11

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85097192772