Synthesis and biological evaluation of cationic TopFluor cholesterol analogues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922272" target="_blank" >RIV/60461373:22330/21:43922272 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/21:00554712 RIV/60461373:22340/21:43922272 RIV/60460709:41210/21:87068
Result on the web
<a href="https://www-sciencedirect-com.ezproxy.vscht.cz/science/article/pii/S0045206821007872?via%3Dihub" target="_blank" >https://www-sciencedirect-com.ezproxy.vscht.cz/science/article/pii/S0045206821007872?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2021.105410" target="_blank" >10.1016/j.bioorg.2021.105410</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and biological evaluation of cationic TopFluor cholesterol analogues
Original language description
Cholesterol is not only a major component of the cell membrane, but also plays an important role in a wide range of biological processes and pathologies. It is therefore crucial to develop appropriate tools for visualizing intracellular cholesterol transport. Here, we describe new cationic analogues of BODIPY-Cholesterol (TopFluorCholesterol, TF-Chol), which combine a positive charge on the sterol side chain and a BODIPY group connected via a C-4 linker. In contrast to TF-Chol, the new analogues TF-1 and TF-3 possessing acetyl groups on the A ring (C-3 position on steroid) internalized much faster and displayed slightly different levels of intracellular localization. Their applicability for cholesterol monitoring was indicated by the fact that they strongly label compartments with accumulated cholesterol in cells carrying a mutation of the Niemann-Pick disease-associated cholesterol transporter, NPC1.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
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Volume of the periodical
117
Issue of the periodical within the volume
2021-11-12
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"nestrankovano"
UT code for WoS article
000711458600006
EID of the result in the Scopus database
2-s2.0-85117729295