Short- and medium-chain chlorinated paraffins in human blood serum of Czech population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922794" target="_blank" >RIV/60461373:22330/21:43922794 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/21:00552852
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0048969721041991?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0048969721041991?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scitotenv.2021.149126" target="_blank" >10.1016/j.scitotenv.2021.149126</a>
Alternative languages
Result language
angličtina
Original language name
Short- and medium-chain chlorinated paraffins in human blood serum of Czech population
Original language description
Short- and medium-chain chlorinated paraffins (SCCPs; MCCPs) are widespread environmental pollutants with bioaccumulation potential and adverse effects on human health. The analysis of blood serum is an important strategy to assess the human exposure to various contaminants, including SCCPs and MCCPs. Lately, the information about the exposure of Chinese population has been reported; nevertheless, data on human exposure to SCCPs and MCCPs outside East Asia are still very limited. In this pilot study, SCCPs and MCCPs were determined in 27 serum samples obtained from Czech adults. The samples were extracted by a three-step extraction (repeated with a clean solvent) by a mixture of n-hexane:diethyl ether (9:1, v/v) with subsequent clean-up on Florisil® solid phase extraction column. Gas chromatography coupled with high resolution mass spectrometry operated in negative chemical ionisation was employed for the instrumental analysis. The method recoveries ranged from 71 to 89% with repeatabilities of <20% (expressed as relative standard deviation). In the samples, SCCP concentrations were in the range of <150–2600 ng/g lipid weight, lw (median 370 ng/g lw) and the MCCP concentrations were in the range of <200–2110 ng/g lw (median 360 ng/g lw), respectively. To the best of our knowledge, our reported results are the first data about chlorinated paraffins in human blood serum in Europe, showing exposure to these compounds with yet to be studied effects on human health. © 2021 Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science of the Total Environment
ISSN
0048-9697
e-ISSN
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Volume of the periodical
797
Issue of the periodical within the volume
149126
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000704363800006
EID of the result in the Scopus database
2-s2.0-85110716032