Colloidal bag of marbles: The structure and properties of lipid-coated silica nanoclusters
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922895" target="_blank" >RIV/60461373:22330/21:43922895 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/21:43922895
Result on the web
<a href="https://doi.org/10.1016/j.colsurfa.2021.127358" target="_blank" >https://doi.org/10.1016/j.colsurfa.2021.127358</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfa.2021.127358" target="_blank" >10.1016/j.colsurfa.2021.127358</a>
Alternative languages
Result language
angličtina
Original language name
Colloidal bag of marbles: The structure and properties of lipid-coated silica nanoclusters
Original language description
Silica particles find applications in drug delivery and bio-sensing, where their large specific surface area can accumulate or release biologically active substances. Such applications would benefit from the ability to control diffusion access to the surfaces of a larger number of silica particles simultaneously. In the present work, we show that a phospholipid bilayer can contain clusters of silica nanoparticles ranging in number from a few to several tens, forming structures resembling a colloidal version of a bag of marbles. The lipidic membrane serves as a diffusion gate that prevents premature leakage of encapsulated substances from the nanoparticles to the bulk during storage, but allows diffusion when the phase transition temperature is exceeded. Using 30 nm SiO2 nanoparticles with or without surface amino groups, combined with lipid membranes containing DPPC, DPPG and cholesterol at molar ratios ranging from 25:60:15–85:0:15, we show that the electrostatic interactions between the nanoparticle surface and the lipid bilayer are crucial for the existence and stability of lipid-coated nanoclusters. We demonstrate the gating mechanism by measuring temperature-dependent diffusion of a model substance 5-(6)-carboxyfluorescein from the clusters. A shift in the phase transition temperature of approx. 20 K has been observed in the lipid-coated silica nanoclusters compared to plain liposomes of identical lipid bilayer composition. © 2021 Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
<a href="/en/project/GA19-09600S" target="_blank" >GA19-09600S: Integrated design methodology of nanoformulation processes for (trans-)dermal delivery of actives</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN
0927-7757
e-ISSN
—
Volume of the periodical
628
Issue of the periodical within the volume
November 2021
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
127358
UT code for WoS article
000702804700003
EID of the result in the Scopus database
2-s2.0-85113661070