Transcriptomic studies of solventogenic clostridia, Clostridium acetobutylicum and Clostridium beijerinckii

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925013" target="_blank" >RIV/60461373:22330/22:43925013 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26220/21:PU142637

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0734975021001956?token=65F420A809147D18F64C5A80C12151A0178C5CEA28F300D9917A30BE49BC15A93BFB1DE7B7132E9E04E6B332DD44C11C&originRegion=eu-west-1&originCreation=20230213093633" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0734975021001956?token=65F420A809147D18F64C5A80C12151A0178C5CEA28F300D9917A30BE49BC15A93BFB1DE7B7132E9E04E6B332DD44C11C&originRegion=eu-west-1&originCreation=20230213093633</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2021.107889" target="_blank" >10.1016/j.biotechadv.2021.107889</a>

Result language

angličtina

Original language name

Transcriptomic studies of solventogenic clostridia, Clostridium acetobutylicum and Clostridium beijerinckii

Original language description

Solventogenic clostridia are not a strictly defined group within the genus Clostridium but its representatives share some common features, i.e. they are anaerobic, non-pathogenic, non-toxinogenic and endospore forming bacteria. Their main metabolite is typically 1-butanol but depending on species and culture conditions, they can form other metabolites such as acetone, isopropanol, ethanol, butyric, lactic and acetic acids, and hydrogen. Although these organisms were previously used for the industrial production of solvents, they later fell into disuse, being replaced by more efficient chemical production. A return to a more biological production of solvents therefore requires a thorough understanding of clostridial metabolism. Transcriptome analysis, which reflects the involvement of individual genes in all cellular processes within a population, at any given (sampling) moment, is a valuable tool for gaining a deeper insight into clostridial life. In this review, we describe techniques to study transcription, summarize the evolution of these techniques and compare methods for data processing and visualization of solventogenic clostridia, particularly the species Clostridium acetobutylicum and Clostridium beijerinckii. Individual approaches for evaluating transcriptomic data are compared and their contributions to advancements in the field are assessed. Moreover, utilization of transcriptomic data for reconstruction of computational clostridial metabolic models is considered and particular models are described. Transcriptional changes in glucose transport, central carbon metabolism, the sporulation cycle, butanol and butyrate stress responses, the influence of lignocellulose-derived inhibitors on growth and solvent production, and other respective topics, are addressed and common trends are highlighted.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20901 - Industrial biotechnology

Project

<a href="/en/project/TN01000048" target="_blank" >TN01000048: Biorefining as circulation technology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biotechnology Advances

ISSN

0734-9750

e-ISSN

1873-1899

Volume of the periodical

58

Issue of the periodical within the volume

Sep 2022

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

nestrankovano

UT code for WoS article

000830105100003

EID of the result in the Scopus database

2-s2.0-85121998802