Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925015" target="_blank" >RIV/60461373:22330/22:43925015 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/22:00001193 RIV/00023736:_____/22:00013382 RIV/00216208:11110/22:10442557

Result on the web

<a href="https://doi.org/10.3390/metabo12020124" target="_blank" >https://doi.org/10.3390/metabo12020124</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/metabo12020124" target="_blank" >10.3390/metabo12020124</a>

Result language

angličtina

Original language name

Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients

Original language description

Lipids modified by oxidative stress are key players in atherosclerosis progression. Superimposed thrombosis with subsequent closure of the coronary artery leads to the clinical manifestation of acute coronary syndrome (ACS). While several studies focusing on alterations in lipid metabolism in the acute phase have been conducted, no information is available on patients’ lipidome alterations over longer time periods. In the current follow-up study, we analyzed plasma samples obtained from 17 patients three years after their ACS event (group AC). Originally, these patients were sampled 3–5 days after an index event (group B). Lipidome stability over time was studied by untargeted lipidomics using high performance liquid chromatography coupled to high resolution mass spectrometry (UHPLC–HRMS). Multi-dimensional statistics used for data processing indicated that plasmalogen lipids were the most prominent lipids separating the above patient groups and that they increased in the follow-up AC group. A similar trend was observed for lysophosphatidylethanolamine (LPE) and phosphatidylethanolamine (PE). The opposite trend was observed for two fatty acyls of hydroxy fatty acid (FAHFAs) lipids and free stearic acid. In addition, a decrease in the “classic” oxitadive stress marker, malondialdehyde (MDA), occurred during the follow-up period. Our findings present unique information about long-term lipidome changes in patients after ACS. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV18-08-00149" target="_blank" >NV18-08-00149: Critical evaluation of the lipidome in acute coronary syndrome and acute stroke patients in correlation with the level of oxidative stress</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Metabolites

ISSN

2218-1989

e-ISSN

2218-1989

Volume of the periodical

12

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

nestrankovano

UT code for WoS article

000761448800001

EID of the result in the Scopus database

2-s2.0-85124156547