Plasma lipidome differences in patients with and without significant carotid plaque

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F24%3A43929057" target="_blank" >RIV/60461373:22330/24:43929057 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/25:00563524 RIV/61383082:_____/24:00001434 RIV/00216208:11110/24:10480019 RIV/00216208:11120/24:43926990 RIV/00064173:_____/24:43926990

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1537189124001034?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1537189124001034?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vph.2024.107377" target="_blank" >10.1016/j.vph.2024.107377</a>

Result language

angličtina

Original language name

Plasma lipidome differences in patients with and without significant carotid plaque

Original language description

Background: Atherosclerosis is a major cause of ischemic stroke, and early detection of advanced atherosclerosis in the carotid artery is important for reducing morbidity and mortality. What is even more important is not only detection of atherosclerosis but early determination whether the patients are at high risk of an event with adverse effects as the size of the plaque does not necessarily reflect its potential to trigger such events. Aim: We studied whether plasma lipidomics profile can be used as a diagnostic tool for stratification of stable or unstable plaques without the need of removing the carotid plaque. Methods: This study used liquid chromatography high-resolution tandem mass spectrometry lipidomics to characterize lipid profiles in patients&apos; plasma and found that patients with significant and complicated (vulnerable) atherosclerotic plaque had distinct lipid profiles compared to those with insignificant plaques. Results: The lipid classes that were most predictive of vulnerable plaque were lysophosphoethanolamines, fatty acyl esters of hydroxy fatty acids, free fatty acids, plasmalogens, and triacylglycerols. Most of these compounds were found decreased in plasma of patients with unstable plaques which enabled sufficient performance of a statistical model used for patient stratification. Conclusions: Plasma lipidomes measured by liquid chromatography-mass spectrometry show differences in patients with stable and unstable carotid plaques, therefore these compounds could potentially be used as biomarkers for unstable plaque in future clinical diagnosis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

VASCULAR PHARMACOLOGY

ISSN

1537-1891

e-ISSN

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Volume of the periodical

155

Issue of the periodical within the volume

neuveden

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

001239652900001

EID of the result in the Scopus database

2-s2.0-85192176054