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Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for human biomonitoring of perfluoroalkyl substances (PFASs) in serum as part of the quality assurance programme under HBM4EU

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43925048" target="_blank" >RIV/60461373:22330/22:43925048 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1016/j.scitotenv.2022.157481" target="_blank" >https://doi.org/10.1016/j.scitotenv.2022.157481</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.scitotenv.2022.157481" target="_blank" >10.1016/j.scitotenv.2022.157481</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for human biomonitoring of perfluoroalkyl substances (PFASs) in serum as part of the quality assurance programme under HBM4EU

  • Original language description

    Perfluoroalkyl substances (PFASs) are of very high concern due to their persistence and accumulative behaviour as well as their manifold adverse health effects. Human biomonitoring (HBM) based on the determination of PFASs in serum samples is an adequate and established strategy for exposure and risk assessment of the population. The suspected health risks associated with exposure levels in the general population call for reliable HBM data verified by Quality Assurance and Quality Control (QA/QC) measures. PFASs were among the chemicals selected as priority substances in HBM4EU, a pan-European project to harmonize and advance HBM within 30 European countries. For this purpose, the analytical comparability and accuracy of PFASs-analysing laboratories was assessed in a QA/QC pro-gramme comprising Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs). This paper presents the evaluation process and discusses the results of four ICI/EQUAS rounds for the determination of eight perfluoroalkyl carboxylic acids and four perfluoroalkyl sulfonic acids (PFBS, PFHxS, PFHpS, PFOS) in serum. All 21 participating laboratories achieved satisfactory results for at least six of these biomarkers, although low limits of quantification (of about 0.1 mu g/L) were required to quantify serum PFAS levels at general pop-ulation exposure levels. The mean relative standard deviation of the participants&apos; results (study RSDR) significantly im-proved from 22 % to 13 % over all PFAS biomarkers in the course of the four rounds. This QA/QC programme succeeded in establishing a network of laboratories with high analytical comparability and accuracy for the analysis of PFASs across 12 European countries.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

  • Continuities

    R - Projekt Ramcoveho programu EK

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Science of the Total Environment

  • ISSN

    0048-9697

  • e-ISSN

    1879-1026

  • Volume of the periodical

    847

  • Issue of the periodical within the volume

    NOV 15 2022

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    nestrankovano

  • UT code for WoS article

    000860613900009

  • EID of the result in the Scopus database

    2-s2.0-85135102412