Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids †

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F22%3A43926040" target="_blank" >RIV/60461373:22330/22:43926040 - isvavai.cz</a>

Result on the web

<a href="https://www-mdpi-com.ezproxy.vscht.cz/1422-0067/23/22/14068" target="_blank" >https://www-mdpi-com.ezproxy.vscht.cz/1422-0067/23/22/14068</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms232214068" target="_blank" >10.3390/ijms232214068</a>

Result language

angličtina

Original language name

Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids †

Original language description

Since not only psilocybin (PSB) but also PSB-containing mushrooms are used for psychedelic therapy and microdosing, it is necessary to know their concentration variability in wild-grown mushrooms. This article aimed to determine the PSB, psilocin (PS), baeocystin (BA), norbaeocystin (NB), and aeruginascin (AE) concentrations in a large sample set of mushrooms belonging to genera previously reported to contain psychotropic tryptamines. Ultra-high performance liquid chromatography coupled with tandem mass spectrometry was used to quantify tryptamine alkaloids in the mushroom samples. Most mushroom collections were documented by fungarium specimens and/or ITS rDNA/LSU/EF1-alpha sequencing. Concentrations of five tryptamine alkaloids were determined in a large sample set of 226 fruiting bodies of 82 individual collections from seven mushroom genera. For many mushroom species, concentrations of BA, NB, and AE are reported for the first time. The highest PSB/PS concentrations were found in Psilocybe species, but no tryptamines were detected in the P. fuscofulva and P. fimetaria collections. The tryptamine concentrations in mushrooms are extremely variable, representing a problem for mushroom consumers due to the apparent risk of overdose. The varied cocktail of tryptamines in wild mushrooms could influence the medicinal effect compared to therapy with chemically pure PSB, posing a serious problem for data interpretation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/NU21-04-00307" target="_blank" >NU21-04-00307: Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

1422-0067

Volume of the periodical

23

Issue of the periodical within the volume

22

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

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UT code for WoS article

000887438400001

EID of the result in the Scopus database

2-s2.0-85142641154