Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985831%3A_____%2F22%3A00563993" target="_blank" >RIV/67985831:_____/22:00563993 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/22:43921004 RIV/61389005:_____/22:00565027
Result on the web
<a href="https://www.mdpi.com/1422-0067/23/22/14068" target="_blank" >https://www.mdpi.com/1422-0067/23/22/14068</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms232214068" target="_blank" >10.3390/ijms232214068</a>
Alternative languages
Result language
angličtina
Original language name
Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids
Original language description
Since not only psilocybin (PSB) but also PSB-containing mushrooms are used for psychedelic therapy and microdosing, it is necessary to know their concentration variability in wild-grown mushrooms. This article aimed to determine the PSB, psilocin (PS), baeocystin (BA), norbaeocystin (NB), and aeruginascin (AE) concentrations in a large sample set of mushrooms belonging to genera previously reported to contain psychotropic tryptamines. Ultra-high performance liquid chromatography coupled with tandem mass spectrometry was used to quantify tryptamine alkaloids in the mushroom samples. Most mushroom collections were documented by fungarium specimens and/or ITS rDNA/LSU/EF1- sequencing. Concentrations of five tryptamine alkaloids were determined in a large sample set of 226 fruiting bodies of 82 individual collections from seven mushroom genera. For many mushroom species, concentrations of BA, NB, and AE are reported for the first time. The highest PSB/PS concentrations were found in Psilocybe species, but no tryptamines were detected in the P. fuscofulva and P. fimetaria collections. The tryptamine concentrations in mushrooms are extremely variable, representing a problem for mushroom consumers due to the apparent risk of overdose. The varied cocktail of tryptamines in wild mushrooms could influence the medicinal effect compared to therapy with chemically pure PSB, posing a serious problem for data interpretation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NU21-04-00307" target="_blank" >NU21-04-00307: Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
23
Issue of the periodical within the volume
22
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
14068
UT code for WoS article
000887438400001
EID of the result in the Scopus database
2-s2.0-85142641154