Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F23%3A43927644" target="_blank" >RIV/60461373:22330/23:43927644 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/23:00579197
Result on the web
<a href="https://www.mdpi.com/1420-3049/28/23/7718" target="_blank" >https://www.mdpi.com/1420-3049/28/23/7718</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules28237718" target="_blank" >10.3390/molecules28237718</a>
Alternative languages
Result language
angličtina
Original language name
Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents
Original language description
The results of the most recent investigation of triterpenoid-based antiviral agents namely in the HIV-1 and HSV-1 treatment were reviewed and summarized. Several key historical achievements are included to stress consequences and continuity in this research. Most of the agents studied belong to a series of compounds derived from betulin or betulinic acid, and their synthetic derivative is called bevirimat. A termination of clinical trials of bevirimat in Phase IIb initiated a search for more successful compounds partly derived from bevirimat or designed independently of bevirimat structure. Surprisingly, a majority of bevirimat mimics are derivatives of betulinic acid, while other plant triterpenoids, such as ursolic acid, oleanolic acid, glycyrrhetinic acid, or other miscellaneous triterpenoids, are relatively rarely involved in a search for a novel antiviral agent. Therefore, this review article is divided into three parts based on the leading triterpenoid core structure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/FV30300" target="_blank" >FV30300: Isolation and application of plant products having effects against stress and other neurodegenerative diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULES
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
28
Issue of the periodical within the volume
23
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
"nestrankovano"
UT code for WoS article
001116026100001
EID of the result in the Scopus database
2-s2.0-85179370220