Selection of Galectin-Binding Ligands from Synthetic Glycopeptide Libraries
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F23%3A43927819" target="_blank" >RIV/60461373:22330/23:43927819 - isvavai.cz</a>
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cplu.202300567" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cplu.202300567</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cplu.202300567" target="_blank" >10.1002/cplu.202300567</a>
Alternative languages
Result language
angličtina
Original language name
Selection of Galectin-Binding Ligands from Synthetic Glycopeptide Libraries
Original language description
Galectins, a class of carbohydrate-binding proteins, play a crucial role in various physiological and disease processes. Therefore, the identification of ligands that efficiently bind these proteins could potentially lead to the development of new therapeutic compounds. In this study, we present a method that involves screening synthetic click glycopeptide libraries to identify lectin-binding ligands with low micromolar affinity. Our methodology, initially optimized using Concanavalin A, was subsequently applied to identify binders for the therapeutically relevant galectin 1. Binding affinities were assessed using various methods and showed that the selected glycopeptides exhibited enhanced binding potency to the target lectins compared to the starting sugar moieties. This approach offers an alternative means of discovering galectin-binding ligands as well as other carbohydrate-binding proteins, which are considered important therapeutic targets.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemPlusChem
ISSN
2192-6506
e-ISSN
2192-6506
Volume of the periodical
neuveden
Issue of the periodical within the volume
2023-12-06
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
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UT code for WoS article
001108728200001
EID of the result in the Scopus database
2-s2.0-85178277997