Steroid-porphyrin conjugate for saccharide sensing in protic media

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F03%3A00008382" target="_blank" >RIV/60461373:22340/03:00008382 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/03:57030257 RIV/61388980:_____/03:57030257 RIV/60461373:22330/03:00008382

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Steroid-porphyrin conjugate for saccharide sensing in protic media

Original language description

A new saccharide receptor in protic media has been designed and synthesized. The receptor combines advantages of steroids, which are responsible for saccharide binding, and of the porphyrin moiety acting as a signalling component of the molecule due to changes in UV-vis electronic spectra. The synthesis is based on condensation of steroid aldehyde with pyrrole to form the porphyrin unit with four protected steroid moieties. After deprotection, meso-substituted porphyrin contains 12-hydroxy groups on thesteroidal part. The receptor is soluble in aqueous solutions and exhibits high complexation affinity towards saccharides. Because the receptor extensively aggregates in water, most of the experiments were performed in 50% aqueous 2-propanol where aggregation is significantly eliminated. Binding is evidenced by spectral changes in the Soret region of the receptor in UV-vis absorption spectra allowing the evaluation of the binding constants. Additional confirmation of binding is obtained

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA203%2F02%2F0420" target="_blank" >GA203/02/0420: Tetrapyrrole Metallocomplexes for Modification of Triplex DNA Structures</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Organic and Biomolecular Chemistry

ISSN

1477-0520

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

19

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

3458-3463

UT code for WoS article

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EID of the result in the Scopus database

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