Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F06%3A00016727" target="_blank" >RIV/60461373:22340/06:00016727 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Interaction of chiral bis-distamycin derivatives with DNAs: electronic circular dichroism study
Original language description
The new diastereomeric complexes of two oligo-N-methylpyrrole peptides, linked by a methano[1,5]-diazocin scaffold with DNA, were prepd. The specificity of the binding modes of (4S,9S)- and (4R,9R)-bis-distamycins deriv. with ct-DNA explains the obsd. optical activity of the racemic mixt. of distamycin if DNA is present. The bis-distamycin deriv. possesses a clear sequence selectivity for A-T rich sequences of DNA, although a nonspecific binding mode with low affinity was also seen for G-C rich sequences. The reversibility of ECD spectra at 5° after heating to 90° was established.
Czech name
Interakce chirálního bis-distamycinu s DNA: Studie elektronickym cirkulárním dichroismem
Czech description
Byly připraveny komplexy dvou oligo-N-methylpyrrolových peptidů spojených methano[1,5]-diazocinem s DNA. Byla pozorována optická aktivita racemické směsi distamycinu v přítomnosti DNA.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tetrahedron Asymmetry
ISSN
09574166
e-ISSN
—
Volume of the periodical
17
Issue of the periodical within the volume
7
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
1049-1055
UT code for WoS article
—
EID of the result in the Scopus database
—