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ANALYSIS OF THE ORTHO EFFECT: BASICITY OF 2-SUBSTITUTED BENZONITRILES

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F06%3A00016732" target="_blank" >RIV/60461373:22340/06:00016732 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/06:00041080

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    ANALYSIS OF THE ORTHO EFFECT: BASICITY OF 2-SUBSTITUTED BENZONITRILES

  • Original language description

    Energies of 18 ortho-substituted benzonitriles and their protonated forms were calculated within the framework of the density functional theory at the level B3LYP/6-311+G(d,p). The substituent effects were evaluated in terms of isodesmic reactions as theeffects on the basicity on the one hand and separately in the nitrile molecules and in the cations on the other. The ortho effect was defined as the difference when compared to the 4-substituted isomers. It is smaller than in the case of ortho-substituted benzoic acids but not negligible (up to 25 kJ mol-1). In unprotonated molecules it may be classified as purely steric effect, in spite of the small dimension of the CN group and estimates made with the calotte models. In the protonated forms, polar properties of the substituent are decisive. In addition, a new, quite important substituent effect was discovered with the substituents OH, SH, CHO and COOCH3, which is controlled by different conformation of protonated and unprotonated mol

  • Czech name

    ANALYSIS OF THE ORTHO EFFECT: BASICITY OF 2-SUBSTITUTED BENZONITRILES

  • Czech description

    Energies of 18 ortho-substituted benzonitriles and their protonated forms were calculated within the framework of the density functional theory at the level B3LYP/6-311+G(d,p). The substituent effects were evaluated in terms of isodesmic reactions as theeffects on the basicity on the one hand and separately in the nitrile molecules and in the cations on the other. The ortho effect was defined as the difference when compared to the 4-substituted isomers. It is smaller than in the case of ortho-substituted benzoic acids but not negligible (up to 25 kJ mol-1). In unprotonated molecules it may be classified as purely steric effect, in spite of the small dimension of the CN group and estimates made with the calotte models. In the protonated forms, polar properties of the substituent are decisive. In addition, a new, quite important substituent effect was discovered with the substituents OH, SH, CHO and COOCH3, which is controlled by different conformation of protonated and unprotonated mol

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Collection of Czechoslovak Chemical Communications

  • ISSN

    0010-0765

  • e-ISSN

  • Volume of the periodical

    71

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    17

  • Pages from-to

    1239-1255

  • UT code for WoS article

  • EID of the result in the Scopus database