Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F06%3A00016747" target="_blank" >RIV/60461373:22340/06:00016747 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
Original language description
Simple water-soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glycolipids and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharicle and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions including ovarian cancer, is selectively detected by the europium complex. LPA is also detected via a fluorescence increase in human plasma samples. The 2-sn-OH moiety of LPA plays a key role in promoting binding to the metal center. Other molecules found in com
Czech name
Lanthanidové komplexy jako fluorescenční indikátory pro neutrální cukry a rakovinné biomarkery
Czech description
Jednoduché ve vodě rozpustné komplexy lanthanu a europia jsou účinné při detekci neutrálních cukrů stejně jako glykolipidů a fosfolipidů V roztocích s pH blízkým fyziologickému se fluorescenční komplexy lanthanu vážou na neutrální cukry s vazebnou konstantou srovnatelnou s arylboronovými kyselinami.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of U.S.A
ISSN
1091-6490
e-ISSN
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Volume of the periodical
103
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
9756-9760
UT code for WoS article
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EID of the result in the Scopus database
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