p38 MAPK plays an essential role in apoptosis induced by photoactivation of a novel ethylene glycol porphyrin derivative

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F08%3A00020239" target="_blank" >RIV/60461373:22340/08:00020239 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/08:00094890

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

p38 MAPK plays an essential role in apoptosis induced by photoactivation of a novel ethylene glycol porphyrin derivative

Original language description

In this study, we provide evidence that photostimulation of various cancer cells preloaded with a new photosensitizing compound, tetrakis-meso-(4-ethyleneglycol-2,3,5,6-tetra-fluorophenyl) porphyrin (PORF-TEG), results in rapid activation of the cell death machinery. PORF-TEG, although primarily localized in lysosomes, induces mitochondria-driven apoptosis. The induction of apoptosis is accompanied by immediate and sustained activation of p38 mitogen-activated protein kinase (MAPK) and transient activation of c-Jun N-terminal kinase (JNK). Conversely, the inhibition of p38 by PD 169316 or SB202190 and by the p38a dominant-negative mutant as well as the deletion of the p38a gene (MEFs-KO) protected cells from apoptosis, whereas inhibition of JNK did not. Activation of the p38 signaling pathway occurs upstream of caspase activation. In addition, preincubation of cells with scavengers of reactive oxygen species attenuated p38 and caspase activation and increased cell survival, thus connec

Czech name

p38 MAPK hraje hlavní roli v apoptóze indukované novým ethylenklykolovým derivátem porfyrinu

Czech description

V této studii jsme prokázali, že fotostimulace různých rakovinných buněk spolu s novou fotosenzitizující látkou, tetrakis-meso-(4-ethylenglykol-2,3,5,6-tetra-fluorofenyl) porfyrin (PORF-TEG), mají za výsledek rychlou aktivaci mechanismu buněčné smrti.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

20

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000255681700008

EID of the result in the Scopus database

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