The evolution of microstructure in three-component granulation and its effect on dissolution
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F08%3A00020747" target="_blank" >RIV/60461373:22340/08:00020747 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The evolution of microstructure in three-component granulation and its effect on dissolution
Original language description
The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder d
Czech name
Vznik mikrostruktury ve třísložkové granulaci a její vliv na rozpouštění
Czech description
Práce popisuje experimentální studii vlivu složení a mikrostruktury granulí obsahujících dva typy primárních částic a pojivo na rychost vylučování složek a celkovou rychlost rozpouštění. Granule byly vytvořeny ve fluidním granulátoru a rychlost rozpouštění byla studována konduktometricky. Poprvé byla experimentálně ověřena existence maxima rozpouštěcí rychlosti v závislosti na obsahu aktivní složky v granuli.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Particulate Science and Technology
ISSN
0272-6351
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
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UT code for WoS article
000252356400007
EID of the result in the Scopus database
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