The effect of granule microstructure on dissolution rate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F08%3A00020745" target="_blank" >RIV/60461373:22340/08:00020745 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The effect of granule microstructure on dissolution rate
Original language description
The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granuleporosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysedusing X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was foun
Czech name
Vliv mikrostruktury granulí na rychlost rozpouštění
Czech description
V této práci je popsána studie vlivu porozity granulí a obsahu a typu pojiva na rychlost jejich rozpouštění. Byly studovány granule dvojího typu ? s pojivem dodávaným jako tavenina a jako roztok. Je ukázáno, že pro danou kombinaci primárních částic a materiálu pojiva je rozhodujícím parametrem pro rozpouštění porozita granulí.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Powder Technology
ISSN
0032-5910
e-ISSN
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Volume of the periodical
181
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
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UT code for WoS article
000253190200003
EID of the result in the Scopus database
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