Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F10%3A00023475" target="_blank" >RIV/60461373:22340/10:00023475 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/10:00049173 RIV/62157124:16370/10:00002607
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans
Original language description
Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from Schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-gamma-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, rubrisandrin A, (-)-gomisin G, (+)-gomisin K-3 and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with theaim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, H-1- and C-13-NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Planta Medica
ISSN
0032-0943
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
15
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
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UT code for WoS article
000283917300007
EID of the result in the Scopus database
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