Isolation of P-glycoprotein inhibitors from Schisandra chinensis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00057525" target="_blank" >RIV/00216224:14110/12:00057525 - isvavai.cz</a>
Result on the web
<a href="http://biomed.papers.upol.cz/incpdfs/pri-990000-0200_10_26.pdf" target="_blank" >http://biomed.papers.upol.cz/incpdfs/pri-990000-0200_10_26.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Isolation of P-glycoprotein inhibitors from Schisandra chinensis
Original language description
Schisandra chinensis (Schisandraceae) is a well-known medicinal plant in traditional Chinese medicine. Recently was found that dibenzocyclooctadiene lignans inhibit ATP binding cassette (ABC) transporters, P-glycoprotein and multidrug resistance-associated protein 1 (MRP1), which export drugs out of the cancer cells. In our previous study, we have isolated nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gamma-schizandrin and wuweizisu C from seeds of Schisandra chinensis and lignans were examined for their effect on doxorubicin-resistant human lung carcinoma COR-L23/R cell line over-expressing MRP1. We have found that two lignans, R-(+)-deoxyschizandrin and R,S-gamma-schizandrin at relatively non-toxic concentrations enhanced the accumulation of doxorubicin in COR-L23/R cells and restored the cytotoxic action of doxorubicin on drug-resistant cells (Slaninová et al.: Toxicology in Vitro 23, 200
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA522%2F07%2F0995" target="_blank" >GA522/07/0995: Regulation of secondary metabolites biosynthesis in cell culture of Schisandra chinensis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů