DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00049176" target="_blank" >RIV/00216224:14110/10:00049176 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R
Original language description
We found that the lignans R-(+)-deoxyschizandrin and R,S-gamma-schizandrin restored the cytotoxic action of the MRP1 substrate doxorubicin to COR-L23/R cells at relatively non-toxic concentrations of the lignans. Deoxyschizandrin and gamma-schizandrin also showed the greatest propensity to enhance the accumulation of doxorubicin in drug resistant cells.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA522%2F07%2F0995" target="_blank" >GA522/07/0995: Regulation of secondary metabolites biosynthesis in cell culture of Schisandra chinensis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Functional Molecules from Natural Sources
ISBN
978-1-84755-259-4
Number of pages of the result
6
Pages from-to
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Number of pages of the book
244
Publisher name
The Royal Society of Chemistry
Place of publication
Cambridge
UT code for WoS chapter
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