Infrared spectroscopic study of the model metal-ligand-antibody systems: What information on the structure and stability of systems can be obtained?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893316" target="_blank" >RIV/60461373:22340/12:43893316 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.vibspec.2012.02.011" target="_blank" >http://dx.doi.org/10.1016/j.vibspec.2012.02.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vibspec.2012.02.011" target="_blank" >10.1016/j.vibspec.2012.02.011</a>

Result language
angličtina
Original language name
Infrared spectroscopic study of the model metal-ligand-antibody systems: What information on the structure and stability of systems can be obtained?
Original language description
In this study we investigated the possibility of using infrared spectroscopy for the characterization of the ligand (diethylenetriaminepentaacetic acid, DTPA) in various aqueous media (water and different buffers), the antibody (immunoglobulin G, IgG), the metal-ligand complexes (Y-DTPA and Lu-DTPA) and the metal-ligand-antibody conjugates (Y-DTPA-IgG and Lu-DTPA-IgG). The aim was to describe behaviour of individual components, and to find spectral markers of complexes and/or conjugates formation. The reason of the choice of Lu and Y was the potential use of their radionuclides to form radiopharmaceutical species for nuclear medicine. We performed kinetic measurements to describe the stability/instability of individual systems. Multivariate data analysis allowed finding out spectral regions related to different chemical processes. Hydrolysis effect of the diethylenetriaminepentaacetic acid dianhydride (cDTPAA) in water was confirmed in unbuffered aqueous solution. Nevertheless, the stu
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/GAP206%2F11%2F0951" target="_blank" >GAP206/11/0951: Development of temperature-dependent measurement techniques of surface-enhanced vibrational spectroscopy for bioanalysis and pharmacy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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