Nonaqueous Capillary Electrophoretic Enantioseparation of Water Insoluble Troger's Base Derivatives Using beta-Cyclodextrin as Chiral Selector

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895230" target="_blank" >RIV/60461373:22340/13:43895230 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/chir.22220/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/chir.22220/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chir.22220" target="_blank" >10.1002/chir.22220</a>

Result language
angličtina
Original language name
Nonaqueous Capillary Electrophoretic Enantioseparation of Water Insoluble Troger's Base Derivatives Using beta-Cyclodextrin as Chiral Selector
Original language description
Racemic mixtures of six Troger's base derivatives were separated by chiral nonaqueous capillary electrophoresis. The separation protocol was optimized first for suitable solvents. Then the applicability of various salts dissolved in organic solvents andtheir mixtures was evaluated. As chiral selectors -cyclodextrin and heptakis(2,6-di-O-methyl)--cyclodextrin at various concentrations were used. The best enantioselectivity for the studied analytes was obtained utilizing formamide as organic nonaqueous solvent containing a mixture of sodium citrate and tris(hydroxymethyl)aminomethane acetate as electrolytes, and -cyclodextrin as chiral additive. The experimental results demonstrated the feasibility of nonaqueous capillary electrophoresis for enantioseparation of Troger's base derivatives. This technique represents a suitable alternative to more commonly used capillary electrophoresis in aqueous environment. Chirality 25:810-813, 2013. (c) 2013 Wiley Periodicals, Inc.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Affinity capillary electromigration methods for selective nanoanalysis of biomolecules and investigation of their interactions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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