Identification of expressed and conserved human noncoding RNAs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F14%3A43897313" target="_blank" >RIV/60461373:22340/14:43897313 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1261/rna.038927.113" target="_blank" >http://dx.doi.org/10.1261/rna.038927.113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.038927.113" target="_blank" >10.1261/rna.038927.113</a>
Alternative languages
Result language
angličtina
Original language name
Identification of expressed and conserved human noncoding RNAs
Original language description
The past decade has shown mammalian genomes to be pervasively transcribed and identified thousands of noncoding (nc) transcripts. It is currently unclear to what extent these transcripts are of functional importance, as experimental functional evidence exists for only a small fraction. Here, we characterize the expression and evolutionary conservation properties of 12,115 known and novel nc transcripts, including structural RNAs, long nc RNAs (lncRNAs), antisense RNAs, EvoFold predictions, ultraconserved elements, and expressed nc regions. Expression levels are evaluated across 12 human tissues using a custom-designed microarray, supplemented with RNAseq. Conservation levels are evaluated at both the base level and at the syntenic level. We combine these measures with epigenetic mark annotations to identify subsets of novel nc transcripts that show characteristics similar to known functional ncRNAs. Few novel nc transcripts show both high expression and conservation levels. However, ov
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA: A Publication of the RNA Society
ISSN
1355-8382
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
236-251
UT code for WoS article
000329850500010
EID of the result in the Scopus database
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