The potential of chiroptical and vibrational spectroscopy of blood plasma for the discrimination between colon cancer patients and the control group

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43899271" target="_blank" >RIV/60461373:22340/15:43899271 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/15:10294888 RIV/00064165:_____/15:10294888
Result on the web
<a href="http://dx.doi.org/10.1039/c4an01880j" target="_blank" >http://dx.doi.org/10.1039/c4an01880j</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c4an01880j" target="_blank" >10.1039/c4an01880j</a>

Result language
angličtina
Original language name
The potential of chiroptical and vibrational spectroscopy of blood plasma for the discrimination between colon cancer patients and the control group
Original language description
Colorectal cancer is one of the most abundant causes of cancer deaths in the world. At an early stage, the established clinical procedures have low reliability and sensitivity. Therefore, we tested a novel approach based on chiroptical methods such as electronic circular dichroism (ECD) and Raman optical activity (ROA). These methods are suitable for detecting slight changes in the 3D structure of chiral biomolecules, some of which may be caused by pathological processes occurring during cancer growth. Fifty-five blood plasma samples were analyzed using the combination of ECD and ROA supplemented by conventional Raman and FT-IR spectroscopy. All obtained spectra were evaluated together by linear discriminant analysis. The accuracy of sample discrimination reached 100% and the subsequent leave-one-out cross-validation resulted in 93% sensitivity and 81% specificity. The achieved results indicate that chiroptical methods supplemented by Raman and FT-IR spectroscopy might be new supporting and minimally invasive tools in the clinical diagnosis of colon cancer.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NT13259" target="_blank" >NT13259: Correlation of plasmatic levels od angiogenteic and immunosupressive factors TGF beta1, VEGF receptors and antitumor cellular immunity (NK, CD8) with therapy response and prognosis in patients with colon cancer.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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