Chiral recognition of bilirubin and biliverdin in liposomes and micelles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43899400" target="_blank" >RIV/60461373:22340/15:43899400 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bpc.2015.06.001" target="_blank" >http://dx.doi.org/10.1016/j.bpc.2015.06.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bpc.2015.06.001" target="_blank" >10.1016/j.bpc.2015.06.001</a>
Alternative languages
Result language
angličtina
Original language name
Chiral recognition of bilirubin and biliverdin in liposomes and micelles
Original language description
The structural formula of biologically important chiral pigments bilirubin and biliverdin differs only by one double bond. We showed that this results in dissimilar interactions with two models of membranes: cationic liposomes composed of 3beta-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol and zwitterionic micelles from 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). While the liposomes recognized the P-form of bilirubin, the micelles recognized its M-form. Both recognized theP-form of biliverdin. Our study also comprised ternary systems consisting of the pigments, model membranes and serum albumin (human and bovine). Bilirubin preferentially interacted with the albumins even in the presence of the liposomes. On the other hand, biliverdin preferred the liposomes. Remarkably, the presence of CHAPS completely changed the biliverdin binding to the protein. Because our study was oriented on different chiral interactions, a chiroptical method of electronic circula
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biophysical Chemistry
ISSN
1873-4200
e-ISSN
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Volume of the periodical
205
Issue of the periodical within the volume
neuvedeno
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
41-50
UT code for WoS article
000358806500006
EID of the result in the Scopus database
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