Design of co-crystallization processes with regard to particle size distribution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900005" target="_blank" >RIV/60461373:22340/15:43900005 - isvavai.cz</a>
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=7&SID=T1fZeoH1ToTyfCMlrRY&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=7&SID=T1fZeoH1ToTyfCMlrRY&page=1&doc=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ces.2015.01.045" target="_blank" >10.1016/j.ces.2015.01.045</a>

Result language
angličtina
Original language name
Design of co-crystallization processes with regard to particle size distribution
Original language description
Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. Advances in crystal engineering have motivated research into the design of pharmaceutical co-crystals. This study examines the formation of agomelatine-citric acid co-crystal in a batch cooling crystallization. Three linear cooling profiles (10 degrees C, 20 degrees C and 30 degrees C/h) were applied for both unseeded and seeded crystallization and the effect of the seeding temperature on the final crystal size distribution was systematically investigated. A mathematical model of the crystallization process, consisting of the population and mass balance, was formulated and solved using the finite difference method. The growth and nucleation rate constants were evaluated iteratively by the comparison of measured and simulated crystal size distributions. The similarities and differences between classical single-component crystallization and co-crystallization were discussed.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
—

Project
<a href="/en/project/GA15-05534S" target="_blank" >GA15-05534S: Structure-property relationships and breakage dynamics of complex granular material</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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