Remote control of enzymatic reaction in compartmentalized microparticles: A system for the delivery of unstable actives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900018" target="_blank" >RIV/60461373:22340/15:43900018 - isvavai.cz</a>
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=19&SID=U1pZHBSPBb1pKRGmC6q&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=19&SID=U1pZHBSPBb1pKRGmC6q&page=1&doc=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ces.2014.06.020" target="_blank" >10.1016/j.ces.2014.06.020</a>

Result language
angličtina
Original language name
Remote control of enzymatic reaction in compartmentalized microparticles: A system for the delivery of unstable actives
Original language description
Control of biochemical reactions in living cells is based on the principle of compartmentalization, whereby the access of substrates to the active sites of enzymes is regulated by the structure of organelles with semi permeable membranes. The present work describes the fabrication of synthetic microparticies with a similar functionality and the possibility to control substrate access to an enzyme remotely by the application of radioirequency (RF) signals. Composite alginate hydrogel microparticles thatcontain iron oxide nanoparticles as local RF susceptors, liposomes that can undergo a reversible phase transition to control the release rate of encapsulated substrate, and an immobilized enzyme (laccase) that facilitates a reaction, were fabricated. Factors affecting the stability and the release kinetics have been investigated and the principle of remotely controllable on demand enzymatic reaction in the particles has been demonstrated. This principle makes it possible to deliver unsta
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
—

Project
<a href="/en/project/GA13-09914S" target="_blank" >GA13-09914S: A controlling of diffusion processes in pores with varying permeability</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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