Network motifs and mechanisms for oscillatory dynamics of biochemical networks

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900369" target="_blank" >RIV/60461373:22340/15:43900369 - isvavai.cz</a>

Result on the web

<a href="https://aiche.confex.com/aiche/2015/webprogram/Paper419744.html" target="_blank" >https://aiche.confex.com/aiche/2015/webprogram/Paper419744.html</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Network motifs and mechanisms for oscillatory dynamics of biochemical networks

Original language description

We formulate and examine detailed mechanisms for a number of enzyme and biochemical oscillatory/signalling networks with the aim of uncovering critical subnetworks that generate the excitable/bistable/oscillatory dynamics. Such core models of the specified nonlinear dynamics are often referred to as network motifs. Our method of finding the motifs is based on a theory of stability of chemical networks known as the stoichiometric network analysis. Given that the mechanism is formulated in terms of mass action kinetics, the instabilities of steady states are linked to topological features of the (sub)network diagrams. This approach enables a classification of biochemical networks. Based on our experimental observations we examine in vitro enzyme reactions including the glucose-glucose oxidase- catalase-hydrogen peroxide reaction, the urea-urease reaction and glucose-glucose oxidase-ferricyanide reactions. Topology of the core oscillatory subnetworks are compared against one another as we

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

<a href="/en/project/LH14009" target="_blank" >LH14009: Instabilities and dynamics of functional motifs in biochemical networks</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of AICHE Annual Meeting 2015

ISBN

978-0-8169-1094-6

ISSN

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e-ISSN

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Number of pages

25

Pages from-to

"72f-01"-"72f-25"

Publisher name

American Institute of Chemical Engineers (AIChE)

Place of publication

New York

Event location

Salt Lake City

Event date

Nov 8, 2015

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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