Reaction networks, oscillatory motifs and parameter estimation in biochemical systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919231" target="_blank" >RIV/60461373:22340/19:43919231 - isvavai.cz</a>
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=E1A626A2nmRBH8c5xhV&page=1&doc=3" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=E1A626A2nmRBH8c5xhV&page=1&doc=3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-28042-0_3" target="_blank" >10.1007/978-3-030-28042-0_3</a>
Alternative languages
Result language
angličtina
Original language name
Reaction networks, oscillatory motifs and parameter estimation in biochemical systems
Original language description
We outline an approach to analysis of dynamics of biosystems formulated as reaction networks. In particular, we discuss stability analysis provided that stoichiometric equations are given for each reaction step together with power law rate expressions. Based on stoichiometry alone, the network at stationary state can be decomposed into elementary subnetworks (elementary modes, extreme currents, fluxes). Assuming power law kinetics, the capacity of the elementary subnetworks for displaying dynamical instabilities, such as bistability and oscillations, is evaluated. These subnetworks are then suitably combined to form the entire network satisfying certain stability constraints implied by experiments. Specifically, we assume that an experimentally measured biosystem represented by a reaction network displays an experimentally observed change from a steady state to oscillations. For the assumed reaction mechanism only a limited set kinetic parameters is known. In contrast, input/output parameters are known from the experiment. The set of unknown kinetic parameters may be estimated by finding a suitable linear combination of elementary modes via linear optimization so that the dynamics displayed by the model fits the experimentally observed behavior. Moreover, reaction network theory is useful in identifying subnetworks that are destabilizing the steady state to yield oscillations. Such subnetworks are called oscillatory motifs and possess a characteristic topology. As an example, we analyze a carbon-nitrogen metabolism of cyanobacteria and examine its oscillatory dynamics.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
<a href="/en/project/GA18-24397S" target="_blank" >GA18-24397S: Constrained analysis of reaction networks - a tool for experimental validation of models of biochemical and photobiological reactors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Lecture Notes in Computer Science
ISBN
—
ISSN
0302-9743
e-ISSN
1611-3349
Number of pages
12
Pages from-to
30-41
Publisher name
Springer International Publishing Switzerland
Place of publication
Cham
Event location
Prague
Event date
Apr 6, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000509932800003