The Use of Reaction Network Theory for Finding Network Motifs in Oscillatory Mechanisms and Kinetic Parameter Estimation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43921405" target="_blank" >RIV/60461373:22340/20:43921405 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007/978-981-15-0422-8_2" target="_blank" >https://link.springer.com/chapter/10.1007/978-981-15-0422-8_2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-981-15-0422-8_2" target="_blank" >10.1007/978-981-15-0422-8_2</a>

Result language
angličtina
Original language name
The Use of Reaction Network Theory for Finding Network Motifs in Oscillatory Mechanisms and Kinetic Parameter Estimation
Original language description
Stoichiometric network analysis (SNA) is a method of studying stability of steady states of reaction systems obeying mass action kinetics. Reaction rates are expressed as a linear combination of elementary subnetworks with nonnegative coefficients (convex parameters) as opposed to standard formulation using rate coefficients and input parameters (kinetic parameters). We present examples of core reaction subnetworks that provide for oscillatory instability. Frequently there is an autocatalytic cycle in the core subnetwork, but in biochemical reactions such cycle is often replaced by a pathway called competitive autocatalysis. Rate coefficients in complex networks are often only partly known. We present a method of estimating the unknown rate coefficients, in which known/measured kinetic parameters and steady state concentrations are used to determine convex parameters, which in turn allows for determination of unknown rate coefficients by solving a set of constraint equations. © 2020, Springer Nature Singapore Pte Ltd.
Czech name
—
Czech description
—

Project
<a href="/en/project/GA18-24397S" target="_blank" >GA18-24397S: Constrained analysis of reaction networks - a tool for experimental validation of models of biochemical and photobiological reactors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Mathematical Analysis and Applications in Modeling ICMAAM 2018
ISBN
978-981-15-0421-1
ISSN
—
e-ISSN
—
Number of pages
11
Pages from-to
13-23
Publisher name
Springer Nature Switzerland
Place of publication
Basel
Event location
Kolkata
Event date
Jan 9, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—

Similar results(10)