Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901964" target="_blank" >RIV/60461373:22340/16:43901964 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpharm.2016.01.023" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2016.01.023</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2016.01.023" target="_blank" >10.1016/j.ijpharm.2016.01.023</a>
Alternative languages
Result language
angličtina
Original language name
Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging
Original language description
The rate of drug release from polymer matrix-based sustained release formulations is often controlled by the thickness of a gel layer that forms upon contact with dissolution medium. The effect of formulation parameters on the kinetics of elementary rate processes that contribute to gel layer formation, such as water ingress, polymer swelling and erosion, is therefore of interest. In the present work, gel layer formation has been investigated by magnetic resonance imaging (MRI), which is a non-destructive method allowing direct visualization of effective water concentration inside the tablet and its surrounding. Using formulations with Levetiracetam as the active ingredient, HPMC as a hydrophilic matrix former and carnauba wax (CW) as a hydrophobic component in the matrix system, the effect of different ratios of these two ingredients on the kinetics of gel formation (MRI) and drug release (USP 4 like dissolution test) has been investigated and interpreted using a mathematical model.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-09914S" target="_blank" >GA13-09914S: A controlling of diffusion processes in pores with varying permeability</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics
ISSN
0378-5173
e-ISSN
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Volume of the periodical
500
Issue of the periodical within the volume
1-2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
136-143
UT code for WoS article
000370049900014
EID of the result in the Scopus database
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