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Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901964" target="_blank" >RIV/60461373:22340/16:43901964 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ijpharm.2016.01.023" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2016.01.023</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ijpharm.2016.01.023" target="_blank" >10.1016/j.ijpharm.2016.01.023</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of hydrophobic inclusions on polymer swelling kinetics studied by magnetic resonance imaging

  • Original language description

    The rate of drug release from polymer matrix-based sustained release formulations is often controlled by the thickness of a gel layer that forms upon contact with dissolution medium. The effect of formulation parameters on the kinetics of elementary rate processes that contribute to gel layer formation, such as water ingress, polymer swelling and erosion, is therefore of interest. In the present work, gel layer formation has been investigated by magnetic resonance imaging (MRI), which is a non-destructive method allowing direct visualization of effective water concentration inside the tablet and its surrounding. Using formulations with Levetiracetam as the active ingredient, HPMC as a hydrophilic matrix former and carnauba wax (CW) as a hydrophobic component in the matrix system, the effect of different ratios of these two ingredients on the kinetics of gel formation (MRI) and drug release (USP 4 like dissolution test) has been investigated and interpreted using a mathematical model.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CI - Industrial chemistry and chemical engineering

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA13-09914S" target="_blank" >GA13-09914S: A controlling of diffusion processes in pores with varying permeability</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Pharmaceutics

  • ISSN

    0378-5173

  • e-ISSN

  • Volume of the periodical

    500

  • Issue of the periodical within the volume

    1-2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    136-143

  • UT code for WoS article

    000370049900014

  • EID of the result in the Scopus database