Double stimuli-responsive polymer systems: How to use crosstalk between pH- and thermosensitivity for drug depots

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43902071" target="_blank" >RIV/60461373:22340/16:43902071 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/16:00462640

Result on the web

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2016.09.010" target="_blank" >http://dx.doi.org/10.1016/j.eurpolymj.2016.09.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2016.09.010" target="_blank" >10.1016/j.eurpolymj.2016.09.010</a>

Result language

angličtina

Original language name

Double stimuli-responsive polymer systems: How to use crosstalk between pH- and thermosensitivity for drug depots

Original language description

We describe a new approach to depot drug deliveryin which a copolymer poly[N-isopropyl acrylamide-co-N-(3-imidazolylpropyl)methacrylamide] (PNIPAM-co-ImPM) is considered as the main object and matrix for a new formulation strategy that provides the controlled and sustained release of an incorporated drug. The relatively low content of ImPM groups (1.6 mol%) was determined to be sufficient to introduce pH-sensitive behavior to the polymer. Together with NIPAM units, which possess a thermo-sensitive behavior, a dual sensitivity was imparted to the polymer that was investigated by means of turbidimetry and dynamic light scattering. A change in pH from 9 down to 4 was observed to result in the increase of the polymer transition temperature from 32 to 70 degrees C. The separation process is also accompanied with the formation of ca. 150-300 nm particles while above the transition temperature. The pH value of approximately 6.5 was defined as a boundary value, where certain properties of the system significantly change. This observation assumes a potential attractiveness of the system for biological applications in which injection is possible using a liquid form at pH ca. 5 without the risk of injection needle obstruction. In this way, a depot is formed at the application site upon simultaneously heating to body temperature and increasing the pH to the physiological value of 7.4. An in vivo experiment using the polymer in PBS (pH = 5.0) with paliperidone as a model drug showed excellent results regarding the release of the drug from a depot. The putative mechanism of action for our depot system is thoroughly described in the article.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Polymer Journal

ISSN

0014-3057

e-ISSN

—

Volume of the periodical

84

Issue of the periodical within the volume

neuvedeno

Country of publishing house

IE - IRELAND

Number of pages

11

Pages from-to

54-64

UT code for WoS article

000390181800005

EID of the result in the Scopus database

2-s2.0-84987850275