Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43902076" target="_blank" >RIV/60461373:22340/16:43902076 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/16:00461365 RIV/68378041:_____/16:00461365 RIV/00216208:11110/16:10325490 RIV/00216275:25310/16:39901497

Result on the web

<a href="http://dx.doi.org/10.1007/s11051-016-3402-5" target="_blank" >http://dx.doi.org/10.1007/s11051-016-3402-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11051-016-3402-5" target="_blank" >10.1007/s11051-016-3402-5</a>

Result language

angličtina

Original language name

Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity

Original language description

Magnetic oxide nanoparticles provide a fascinating tool for biological research and medicine, serving as contrast agents, magnetic carriers, and core materials of theranostic systems. Although the applications rely mostly on iron oxides, more complex oxides such as perovskite manganites may provide a much better magnetic performance. To assess the risk of their potential use, in vitro toxicity of manganite nanoparticles was thoroughly analysed and compared with another prospective system of Mn-Zn ferrite nanoparticles. Magnetic nanoparticles of La0.63Sr0.37 MnO3 manganite were prepared by two distinct methods, namely the molten salt synthesis and the traditional sol-gel route, whereas nanoparticles of Mn0.61Zn0.42Fe1.97O4 ferrite, selected as a comparative material, were synthesized by a new procedure under hydrothermal conditions. Magnetic cores were coated with silica and, moreover, several samples of manganite nanoparticles with different thicknesses of silica shell were prepared. The size-fractionated and purified products were analysed using transmission electron microscopy, dynamic light scattering, measurement of the zeta-potential dependence on pH, IR spectroscopy, and SQUID magnetometry. The silica-coated products with accurately determined concentration by atomic absorption spectroscopy were subjected to a robust evaluation of their cytotoxicity by four different methods, including detailed analysis of the concentration dependence of toxicity, analysis of apoptosis, and experiments on three different cell lines. The results, comparing two manganese-containing systems, clearly indicated superior properties of the Mn-Zn ferrite, whose silica-coated nanoparticles show very limited toxic effects and thus constitute a promising material for bioapplications.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BM - Solid-state physics and magnetism

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Nanoparticle Research

ISSN

1388-0764

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

18

Pages from-to

"18:100"

UT code for WoS article

000373861400006

EID of the result in the Scopus database

2-s2.0-84962745880