Immobilized strychnine as a new chiral stationary phase for HPLC
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43913118" target="_blank" >RIV/60461373:22340/17:43913118 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10368237 RIV/00216208:11110/17:10368237
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/elps.201600505/abstract;jsessionid=2A786D9B0FA42CE5055686403A6C39AC.f02t04" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/elps.201600505/abstract;jsessionid=2A786D9B0FA42CE5055686403A6C39AC.f02t04</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elps.201600505" target="_blank" >10.1002/elps.201600505</a>
Alternative languages
Result language
angličtina
Original language name
Immobilized strychnine as a new chiral stationary phase for HPLC
Original language description
A new ion-exchanger type chiral stationary phase for high-performance liquid chromatography was prepared. The synthetic protocol is based on derivatization of silica with (3-iodopropyl) trimethoxysilane in the first step followed by immobilization of strychnine via quaternization of nitrogen atom of the alkaloid strychnine. The synthesized chiral stationary phase was chromatographically characterized. The main effort was headed towards the evaluation of the enantioselectivity of the novel sorbent. For that purpose a set of suitable chiral probes, specifically, binaphthyl derivatives, was employed. The influence of methanol content, concentration of aqueous ammonium acetate buffer, and its pH on retention factors, separation selectivity, and resolution of the atropoisomers of the mentioned chiral solutes was studied in detail. It was demonstrated that the new chiral stationary phase was capable to separate atropoisomers of four out of seven testing compounds. Despite the strong influence of the above mentioned variables on retention, their impact on selectivity and resolution was rather moderate. Concerning retention mechanism, it seems that electrostatic interaction between the positively charged quaternary nitrogen of the chiral stationary phase and anionic solute participates significantly in the retention process.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electrophoresis
ISSN
0173-0835
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
Neuvedeno
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
1956-1963
UT code for WoS article
000406724200017
EID of the result in the Scopus database
2-s2.0-85019359726